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All About Lulu by Jonathan Evison

In the wake of his mother's death, as his body-building father and brothers pump themselves to Hulkish proportions, weak-eyed vegetarian William Miller stops growing altogether--until his father remarries a relentlessly kind grief counselor, delivering Will a troubled stepsister who soon becomes his confessor, companion, and heart's only desire. But when Lulu inexplicably begins to push him away, Will is forced to look elsewhere for meaning.